Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Descrição
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://journals.physiology.org/cms/10.1152/physrev.00047.2019/asset/images/medium/prv-00047-2019r01.png)
RNA-binding proteins balance brain function in health and disease
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.mdpi.com/ijms/ijms-22-06579/article_deploy/html/images/ijms-22-06579-g001.png)
IJMS, Free Full-Text
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41380-020-0821-6/MediaObjects/41380_2020_821_Fig4_HTML.png)
Dissociation of functional and structural plasticity of dendritic spines
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrn4001/MediaObjects/41583_2015_Article_BFnrn4001_Fig1_HTML.jpg)
Dysregulation and restoration of translational homeostasis in
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://ars.els-cdn.com/content/image/3-s2.0-B978012800109700008X-f08-01-9780128001097.jpg)
FMRP and the Pathophysiology of Fragile X Syndrome - ScienceDirect
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fncomms11020/MediaObjects/41467_2016_Article_BFncomms11020_Fig1_HTML.jpg)
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsj.npp.1301610/MediaObjects/41386_2008_Article_BF1301610_Fig1_HTML.jpg)
Fragile X: Translation in Action
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://pub.mdpi-res.com/ijms/ijms-19-02280/article_deploy/html/images/ijms-19-02280-ag.png?1570340478)
IJMS, Free Full-Text
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.pnas.org/cms/10.1073/pnas.2109448119/asset/031ae75a-08c5-4d2f-8892-d8b50f18722e/assets/images/large/pnas.2109448119fig04.jpg)
Pten heterozygosity restores neuronal morphology in fragile X
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.mdpi.com/ijms/ijms-23-06315/article_deploy/html/images/ijms-23-06315-g003-550.jpg)
IJMS, Free Full-Text
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.jneurosci.org/content/jneuro/31/2/725/F6.large.jpg)
Dual Regulation of Fragile X Mental Retardation Protein by Group I
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs11689-011-9074-7/MediaObjects/11689_2011_9074_Fig1_HTML.gif)
Targeted treatments for fragile X syndrome
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41380-020-0821-6/MediaObjects/41380_2020_821_Fig1_HTML.png)
Dissociation of functional and structural plasticity of dendritic
de
por adulto (o preço varia de acordo com o tamanho do grupo)