Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect
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Enrichment of NPC1-deficient cells with the lipid LBPA stimulates
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://www.embopress.org/cms/asset/d4816146-c0ff-4c4a-852f-c43145263d88/embr201948143-abs-0001-m.jpg)
NPC1 enables cholesterol mobilization during long‐term
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://www.asbmb.org/getmedia/b16a2171-a217-45a1-9786-fe43e8c8c5af/npc-figure-primary_1.jpg)
From genes to hope
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124719305790-gr6.jpg)
Niemann-Pick Type C Disease Reveals a Link between Lysosomal
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://www.researchgate.net/publication/23248158/figure/fig1/AS:394492042596352@1471065640398/Lipid-trafficking-defects-in-Niemann-Pick-type-C-disease.png)
Lipid trafficking defects in Niemann-Pick type C disease
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://www.cell.com/cms/attachment/29149c74-7a63-4717-a4d3-9ea51ca28043/gr1_lrg.jpg)
Critical role for glycosphingolipids in Niemann-Pick disease type
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0163782723000152-gr2.jpg)
The Niemann-Pick type diseases – A synopsis of inborn errors in
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://www.thelancet.com/cms/asset/7294670e-4914-40f6-84dc-37a1b313ce02/gr3.jpg)
Juvenile CLN3 disease is a lysosomal cholesterol storage disorder
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0022227520435795-gr4.jpg)
Mass spectrometry imaging and LC/MS reveal decreased cerebellar
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://assets.medlink.com/content/article-media/npmv1b.jpg)
Niemann-Pick disease type C
![Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect](https://cdn.lecturio.com/assets/Lysosomal-storage-pathway.png)
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